Somatostatin receptor expression in parathyroid neoplasms
نویسندگان
چکیده
منابع مشابه
Somatostatin receptor expression in thymic tumors.
Detection of thymic tumors by (111In-DTPA0)octreotide scintigraphy and the antitumor effect exerted by somatostatin (SS) analogs suggest significant expression of SS receptors (SSRs) in these tumors. We measured SSR subtype (sst)2A and sst3 expression by immunohistochemistry (IHC) in 14 thymic tumors previously studied by SSR scintigraphy (SRS). Scintigraphy showed significant (111In-DTPA0)octr...
متن کاملSomatostatin receptor subtype expression in human tumors.
The presence of functional SSR in tumors has several clinical implications which include the possibility a) to control hormonal hypersecretion and related symptomatology by treatment with SS-analogs, b) to detect SSR positive tumors and their metastases by in vivo SSR scintigraphy, and c) to carry out SSR-targeted radiotherapy using radiolabeled SS-analogs. The majority of SSR positive tumors s...
متن کاملSomatostatin receptor subtype expression and function in human vascular tissue.
In animal models the somatostatin analog angiopeptin inhibits intimal hyperplasia by acting primarily through somatostatin receptor 2 (SSTR-2). However, the results of clinical trials using angiopeptin have been disappointing. In this study we showed that human blood vessels express high levels of SSTR-1 with significantly lower levels of SSTR-2 and -4. Samples of normal veins and arteries, as ...
متن کاملExpression of somatostatin subtype 1 receptor in the rabbit retina.
PURPOSE To detect mRNAs for somatostatin (somatotropin release-inhibiting factor [SRIF]) receptor subtypes 1 to 5 (sst(1) through sst(5)) in rabbit retinas by reverse transcription-polymerase chain reaction (RT-PCR) and to investigate the distribution of sst(1) by single- and double-label immunocytochemistry. METHODS Semiquantitative RT-PCR using sst-specific primers from mouse sequences was ...
متن کاملSomatostatin receptor expression in non-medullary thyroid carcinomas.
OBJECTIVE Peptide receptor radionuclide therapy (PRRT) is dependent upon binding of radiolabelled peptides to their respective receptor expressing cells. The main objective of this study was to characterize the expression of somatostatin receptor (SSTR) subtypes in non-medullary thyroid cancers in order to be able to recommend the use of PRRT as a treatment option in patients with progressive l...
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ژورنال
عنوان ژورنال: Endocrine Connections
سال: 2019
ISSN: 2049-3614,2049-3614
DOI: 10.1530/ec-19-0260